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Comparison of thyroid profile in premenopausal and postmenopausal women: A case control study

G.S. Chandrashekhar


Introduction : After menopause, diminishedgonadal hormones are found to influence thyroid status. There are a few published literature in this area, to the best of our knowledge. Aim of the study was to compare thyroid profile of postmenopausal women with those in reproductive age group as well as to find the correlation between age and thyroid profile. compare thyroid profiles of young men with those in geriatric age group iii. find if anygender differences in thyroid profiles. Methods: In a case control study, thyroid profiles of 76 post menopausal women and 131 women in reproductive age group were compared. Thyroid profile of 78 young men was compared with that of 24 men in geriatric age group. Gender differences in thyroid profile were studied by comparing thyroid profiles of 207 women and 102 men. Statistical analysis was carried out using MannWhitney U test and Linear regression analysis. Results: A significantly higher TSH levels (P<0.05) and decreased T3 (P<0.0001) were observed in postmenopausal women compared to the controls. There was no statistically significant difference in thyroid profiles among men in geriatric age group and young men. There was a significant elevation of TSH in women compared to men (P<0.05). A negative correlation between age and T3 levels was observed in women. Conclusion: Subclinical hypothyroidism was observed in post menopausal women in our setting. A higher tendency of women having subclinical hypothyroidism compared to men was also observed. This suggestsa necessity to assess functional status of thyroid gland periodically in the post menopausal period.

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Cooper DS. Thyroid disease in the oldest old: the exception to the rule. JAMA. 2004 Dec 1;292(21):2651-4. DOI:10.1001/jama.292.21.2651

Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004 Jan 14;291 (2): 228-38.DOI:10.1001/jama.291.2.228

Suzuki S, Nishio S, Takeda T, Komatsu M. Gender-specific regulation of response to thyroid hormone in aging. Thyroid Res. 2012 Jan 26;5(1):1. doi: 10.1186/ 1756-6614-5-1.

Pearce NE. Thyroid dysfunction in perimenopausal and postmenopausal women. Boston University Medical Center, Boston, Massachusetts, USA Meno-pause Int. 2007;13(1):8-13.

Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002 Feb; 87 (2): 489-99.DOI:10. 1210 / jcem.87.2.8182

Usha Adiga. Thyroid Status, Renal Profile and Electrolytes in Postmenopausal Women. International Journal of Biochemistry Research and Review 2017;18 (1):1-5.

Rojas LV, Nieves K, Suarez E, et al. Thyroid-stimulating hormone and follicle-stimulating hormone status in Hispanic women during the menopause transition.Ethn Dis.2008 Spring;18(2 Suppl 2):S2-230-4

Benhadi N, Fliers E, Visser TJ, et al. Pilot study on the assessment of the setpoint of the hypothalamus-pituitary-thyroid axis in healthy volunteers. Eur J Endocrinol. 2010 Feb;162(2):323-9. doi: 10.1530/EJE-09-0655. Epub 2009 Nov 19.

Chahal HS, Drake WM. The endocrine system and ageing. J Pathol. 2007 Jan;211(2):173-80.DOI:10.1002/ path.2110

Mariotti S, Barbesino G, Caturegli P, et al. Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab. 1993 Nov;77(5):1130-4.DOI: 10.1210/jcem.77.5.8077303

Hershman JM, Pekary AE, Berg L, et al. Serum thyrotropin and thyroid hormone levels in elderly and middle-aged euthyroid persons. J Am Geriatr Soc. 1993 Aug; 41(8):823-8.

Heuck CC, Kallner A, Kanagasabapathy AS, Riesen W. WHO Document (WHO/DIL /00.4) on “Diagnosis and monitoring of diseases of the thyroid”, 2000.

Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf). 2003 Feb;58(2):138-40.

Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. EndocrPract. 2012 Nov-Dec; 18(6):988-1028. DOI:10.4158/EP12280.GL

Brabant G, Prank K, Ranft U, et al. Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman. J Clin Endocrinol Metab. 1990 Feb;70(2):403-9.DOI:10. 1210 / jcem-70-2-403

Kuokkanen, S, Santoro, N. Endocrinology of the Perimenopausal Woman. Glob. libr. women's med. (ISSN: 1756-2228) 2011; doi: 10. 3843/ GLOWM. 10082.


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