Study of Reproductive & Thyroid Hormones in adolescent with Sickle Cell Disease

Sharja Phuljhele, Virendra K Kurrey, Akanksha Verma, Kanwaljeet Singh Hura

Abstract


Introduction: Sickle cell anaemia patients have been reported to suffer from endocrine dysfunctions which often have an influence on growth, development, and metabolism. Delayed somatic and sexual developments have been well described in patients with homozygous sickle cell disease. The present study focuses plasma levels of seven different endocrine hormones in individuals aged between 10-18 years, with a diagnosis of homozygous sickle cell disease. Material & methods: All study subjects were undergone for estimation of follicular stimulating hormone (FSH), Leuteinizing Hormone (LH), Testosterone, T3, T4 & TSH measured and value were analyse statistically. Observation: Study Patients with sickle cell disease showed LH, FSH Testosterone and Estradiol are significantly reduced in individual with homozygous sickle cell disease (SS) in comparison with control group suggest that the sickle cell gene abnormality has an adverse effect on endocrine functions. Conclusion: Routine screening for endocrine dysfunctions are advocated in all adolescent sickle cell disease patient.

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References


Negi RS (1972) Sickle cell trait in India. A review of known distribution. Bull Anthropol Surv India 17:439–449

Balgir RS. Genetic epidemiology of the three predominant abnormal hemoglobins in India. J Assoc Physicians India. 1996 Jan;44(1):25-8.

Ambekar SS, Phadke MA, Mokashi GD, Bankar MP, Khedkar VA, Venkat V, Basutkar DG. Pattern of hemoglobinopathies in western Maharashtra. Indian Pediatr. 2001 May;38(5):530-4.

Patra PK, Chauhan VS, Khodiar PK, Dalla AR, Serjeant GR. Screening for the sickle cell gene in Chhattisgarh state, India: an approach to a major public health problem. J Community Genet. 2011 Sep;2(3):147-51. doi: 10.1007/s12687-011-0050-4. Epub 2011 Jun 15.

Balgir RS, Sharma SK. Distribution of sickle cell hemoglobin in India. Indian J Hemat 1988, 6: 1-14.

Ambekar SS, Phadke MA, Mokashi GD, Bankar MP, Khedkar VA, Venkat V, Basutkar DG. Pattern of hemoglobinopathies in western Maharashtra. Indian Pediatr. 2001 May;38(5):530-4.

PROJECT IMPLEMENTATION PLAN 2012-13, CHHATTISGARH cg.nic.in/health/programonitoring/PIPHealthFinancing/PIP201213.

Platt OS, Rosenstock W, Espeland MA. Influence of sickle hemoglobinopathies on growth and development. N Engl J Med. 1984 Jul 5;311(1):7-12.

Ashcroft MT, Serjeant GR, Desai P. Heights, weights, and skeletal age of Jamaican adolescents with sickle cell anaemia. Arch Dis Child. 1972 Aug;47(254):519-24.

Olambiwonnu NO, Penny R, Frasier SD. Sexual maturation in subjects with sickle cell anemia: studies of serum gonadotropin concentration, height, weight, and skeletal age. J Pediatr. 1975 Sep;87(3):459-64.

Abbasi AA, Prasad AS, Ortega J, Congco E, Oberleas D. Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients. Ann Intern Med. 1976 Nov;85(5):601-5.

Dada OA, Nduka EU. Endocrine function and haemoglobinopathies: relation between the sickle cell gene and circulating plasma levels of testosterone, luteinising hormone (LH) and follicle stimulating hormone (FSH) in adult males. Clin Chim Acta. 1980 Aug 4;105(2):269-73.

Landefeld CS, Schambelan M, Kaplan SL, Embury SH. Clomiphene-responsive hypogonadism in sickle cell anemia. Ann Intern Med. 1983 Oct;99(4):480-3.

Adadevoh BK. Haemoglobin sickle-cell disease and Sheehan's syndrome. Br J Clin Pract. 1968 Oct;22(10):442-3.

el-Hazmi MA, Bahakim HM, al-Fawaz I. Endocrine functions in sickle cell anaemia patients. J Trop Pediatr. 1992 Dec;38(6):307-13.

Modebe O, Ezeh UO. Effect of age on testicular function in adult males with sickle cell anemia. Fertil Steril. 1995 Apr;63(4):907-12.

Morrison, Belinda, Et Al. "1316 Hypogonadism, Bone Mineral Composition And Lipid Abnormalities In Adult Male Patients With Sickle Cell Disease. The Journal Of Urology 185.4 (2011): E526-E527.

Lukanmbi FA et al. (1986) Endocrine function and haemoglobinopathies: biochemical assessment of thyroid function in children with sickle cell disease. AfrJ Med Med Sci 15: 25-28.

Osegbe DN, Akinyanju OO. Testicular dysfunction in men with sickle cell disease. Postgrad Med J. 1987 Feb;63(736):95-8.

Emmanuel K Abudu, Sulaiman A Akanmu, Oyetunji O Soriyan, Akinsegun A Akinbami, Adewumi Adediran, Titilope A Adeyemo and Charles C Okany. Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos,Nigeria. BMC Research Notes 2011,4:298.

Taddesse A , Woldie IL, Khana P, Swerdlow PS, Chu JW, Abrams J, Abou-Samra AB. Hypogonadism in Patients with Sickle Cell Disease: Central or Peripheral?. Acta Haematol. 2012;128(2):65-8. doi:10.1159/000337344.Epub 2012 Jun6.


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