A retrospective study of female breast cancer: Stage and age correlation

Sushil Damodardas Akruwala, Vidhyasagar M Sharma

Abstract


Background: With 1 million new cases in the world each year, breast cancer is the commonest malignancy in women and comprises 18% of all female cancers. At present carcinoma breast is the leading cancer in India and is competing cancer cervix in incidence. Epidemiological studies at regional and global levels suggest the occurrence of carcinoma breast at a younger, premenopausal age in Indian and Asian women as compared with western women. Knowledge of this factor emphasizes the need to modify the timing of modalities of detection of early carcinoma and its management. According to literature, majority of carcinoma breast cases in the western countries present in Stages I and II of the disease whereas in India majority cases present in Stage III of the disease. The objective of this study is to observe and study age correlation with female breast cancer. Methods: A retrospective study was conducted in 267 patients of histopathologically confirmed breast cancer. Results: Mean age of subjects was 44.34±8.55 years. Age distribution showed peaks at 41-50 years with 134 patients. This study shows that 71.90% of the total patients were having advanced carcinoma breast (Stage III, IV) and 73.7% of these patients were below 50 years of age. Conclusions: Breast cancer is increasingly occurring in younger age groups in India when compared with western countries and a more aggressive nature of the disease strikes in their reproductive period suggesting the need for change in modalities of early cancer detection and adjusting preventive and therapeutic efforts.


Full Text:

PDF HTML

References


Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001 Oct 15; 94 (2):153-6.

Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. DOI: 10.1111/ajco.12661

Kakarala M, Rozek L, Cote M, et al. cancer histology and receptor status characterization in Asian Indian and Pakistaniwomen in the U.S.--a SEER analysis. DOI:10.1186/1471-2407-10-191

Advani S. Partner profile: Cancer in India. INCTR News. 2004;5:18.

Leong SP, Shen ZZ, Liu TJ, et al. Is breast cancer the same disease in Asian and Western countries? DOI:10. 1007/s00268-010-0683-1

Anderson WF, Pfeiffer RM, Dores GM, Sherman ME. Comparison of age distribution patterns for different histopathologic types of breast carcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1899-905. doi:10.1158/1055-9965. EPI-06-0191.

Saxena S, Rekhi B, Bansal A, Bagga A, Chintamani, Murthy NS. Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India - A cross-sectional study. World J Surg Oncol. 2005; 3: 67.doi: 10.1186/1477-7819-3-67.

Anderson WF, Reiner AS, Matsuno RK, Pfeiffer RM. Shifting breast cancer trends in the United States. DOI: 10. 1200/ JCO. 2007.11.6079

Goel A, Bhan CM, Srivastava KN. Five yearclinico pathological study of breast cancer. Indian J Med Sci. 2003 Aug; 57 (8):347-9.

Chopra B, Kaur V, Singh K, Verma M, Singh S, Singh A. Age shift: Breast cancer is occurring in younger age groups - Is it true?. Clin Cancer Investig J. 2014; 3 :526-9.doi: 10.4103/2278-0513.142652.

National Cancer Registry Programme (ICMR). Consolidated Report of Population Based Cancer Registries 2001-2004. Individual Registry Data. 2001-2003;161.

Sandhu DS, Sandhu S, Karwasra RK, Marwah S. Profile of breast cancer patients at a tertiary care hospital in north India. DOI:10.4103/0019-509X.58853

Hulvat MC, Hansen NM, Jeruss JS. Multi-disciplinary care for patients with breast cancer. DOI: 10. 1016/j.suc.2008.10.002

Chauhan A, Subba SH, Menezes RG, et al. Younger women are affected by breast cancer in South India - a hospital-based descriptive study. Asian Pac J Cancer Prev. 2011;12(3):709-11.


Refbacks

  • There are currently no refbacks.