A prospective study of serum zinc levels in children presenting with simple febrile seizures

Sowjan M.

Abstract


Aim: To estimate the levels of serum zinc in children with simple febrile seizures and to compare serum zinc levels between children with febrile seizures and febrile children without seizures. Materials and Methods: A prospective case control study was done on 100 children for a period of one year from June 2018 to January 2019, admitted in Karpaga Vinayaga Institute of Medical Sciences, Padalam, Chennai, who satisfied the inclusion and exclusion criteria. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 children. Results: Mean Serum zinc levels in children with febrile seizures were 58.4 micrograms/dl and mean serum zinc levels in control group was 94.1 micrograms/dl (p=0.0001). Serum zinc levels were significantly low in children who had febrile seizures of prolonged duration (p=0.0001). Conclusion: These findings revealed that there is correlation between serum zinc and simple febrile seizures. Serum zinc level was significantly lower in children with simple febrile seizures in comparison with febrile children without seizure.

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Kleigman RM, Stanton BF, Schor NF, St. Geme JW, Bherman RE. Nelson textbook of paediatrics, 19 ed. Philadelphia, PA: saunders; 2011.

Doose H, Maurer A. Seizure risk in offspring of individuals with a history of febrile convulsions. Eur J Pediatr. 1997 Jun;156(6):476-81.

Mollah MA, Dey PR, Tarafdar SA, et al. Zinc in CSF of patients with febrile convulsion. Indian J Pediatr. 2002 Oct; 69 (10):859-61.

OP Mishra, Deepak Singhal, Ram S Upadhyay, Rajniti Prasad And DivyaAtri. Cerebrospinal fluid zinc, magnesium, copper and gamma-aminobutyric acid levels in febrile seizures. journal of pediatric neurology 2007; 5(1): 39-44.

Peters S, Koh J, Choi DW. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science. 1987 May 1;236(4801):589-93.

Graves RC, Oehler K, Tingle LE. Febrile seizures: risks, evaluation, and prognosis. Am Fam Physician. 2012 Jan 15;85(2):149-53.

Patterson JL, Carapetian SA, Hageman JR, et al. Febrile seizures. Pediatr Ann. 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09.

Stafstrom CE. The incidence and prevalence of febrile seizures.In: Baram TZ, ShinnarS, editors. Febrile seizures. San Diego: Academic Press; 2002. pp. 1–25.

Fukahori M, Itoh M. Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in the El (epilepsy) mouse. Brain Res. 1990 Oct 8;529(1-2): 16-22.

Ganesh R, Janakiraman L. serum zinc levels in children with simple febrile seizures. clinical paediatrics 2008; 47(2):164-166.

Salehiomran MR, Mahzari M. Zinc status in febrile seizure: a case-control study. Iran J Child Neurol. 2013 Fall; 7 (4):20-3.

Heydarian F, Ashrafzadeh F, Ghasemian A. Serum zinc level in patient with simple febrile seizure. Iran J Child Neurol 2010; 4(2):41-43.

Cho WJ, Son BH, Kim SW. Levels of Sodium and Zinc concentration in febrile convulsion. Korean Child Neural Soc 1999; 7(2): 214-219.

Garty BZ, Olomucki R, Lerman-Sagie T, et al. Cerebrospinal fluid zinc concentrations in febrile convulsions. Arch Dis Child. 1995 Oct;73(4):338-41.

Burtis carl A, Ashwood Edwhard R, Brun David E. Tietz fundamentals of clinical chemistry, 6th ed. Philadelphia: saunders; 2005.505-507

Smart TG, Hosie AM, Miller PS. Zn2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist. 2004Oct;10(5):432-42. DOI:10. 1177/1073858404263463

Mollah MA, Rakshit SC, Anwar KS, et al. Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: findings from a prospective study in Bangladesh. Acta Paediatr. 2008 Dec; 97 (12): 1707-11. doi: 10. 1111/j. 1651-2227.2008.01001.x.Epub 2008 Sep 15.


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