Cover Image

Prevalence of hepatobiliary dysfunction and ultrasonographic abnormalities in dengue fever in pediatric age group

Madhusudan S.R., Prabhavathi R, Suman M.G., Govindaraj M., Puttaswamy M.

Abstract


Introduction: High morbidity and mortality in DF/DHF is due to multiorgan involvement. Hepatic involvement can present with varied manifestations ranging from hepatomegaly to fulminant hepatic failure. Incidence of hepatic dysfunction is more in Dengue shock syndrome and Dengue hemorrhagic fever. Ultrasound can be used as a prognostic indicator and also used as means of monitoring for plasma leakage. Objectives: To study the clinical presentation, hepatic abnormalities and the ultrasonographic findings in dengue fever, dengue haemorrhagic fever and dengue shock syndrome and to correlate these findings with the severity of dengue fever. Materials and Methods: 100 hospitalized patients of Dengue fever were classified as DF/DHF/DSS as per their clinical manifestations. Lab investigations namely SGOT, SGPT, PT, APTT and INR were monitored. Ultrasonography of the abdomen and thorax were done. Hepatic enzymes, coagulation workup and ultrasonographic parameters in DF/DHF/DSS were compared in the study. Conclusion: Severe dengue can pose challenges to the treating physician. Hence early identification of deterioration in the clinical status can be reasonably assessed by using hepatic and ultrasound parameters which will help in the management of dengue illness and thus reducing the mortality and morbidity.


Full Text:

PDF HTML

References


National Guidelines for Clinical Management of Dengue Fever. WHO, 2014. www.nvbdcp.gov.in (accessed on 10th July 2018).

Bokade C M., Chauhan Urmila and Kamat Pranoti. 2016, Study of Hepatic Dysfunction In Dengue Fever And It’s Predictor of Outcome. Int J Recent Sci Res. 7(9), pp. 13360-13363.

Selvan, Tamil &Lp, Joy & Souza, D & Swamy, Narayana & Kumar, Mahesh. (2015). ISSN 2347-954X (Print) Prevalence and severity of Thrombocytopenia in Dengue fever in children.

Srinivasa S, Tanveer Nawab, Chaithanya C Nair, Clinical profile and ultasonogaphic findings in children with dengue fever. CurrPediatr Res 2014 Volume 18 Issue 2: 87-90

Nawale A, Joshi M, Borde A, Role of Ultrasound in Dengue Infection, International Journal of Science and Research (IJSR) Volume 5 Issue 10, October 2016: 1478-87, Paper ID: ART20162478

Bandyopadhyay D, Chattaraj S, Hajra A, Mukho-padhyay S, Ganesan V. A Study on Spectrum of Hepatobiliary Dysfunctions and Pattern of Liver Involvement in Dengue Infection. J Clin Diagn Res. 2016 May; 10(5):OC21-6. doi: 10.7860/JCDR/2016/ 16946. 7784. Epub 2016 May 1.

Mohan B, Patwari A. K, and Anand V.K. Hepatic Dysfunction in Childhood Dengue Infection, Journal of Tropical Pediatrics,Volume 46, 2000 Feb;40-45.

Jagadishkumar K, Jain P, Manjunath VG, Umesh L. Hepatic involvement in dengue Fever in children.Iran J Pediatr. 2012 Jun; 22(2):231-6.

Villar Barbosa de Oliveira, Ricardo & Rios, Lívia & dos Remédios Freitas Carvalho Branco, M & Braga Jr, L.L. & Moucherek Soares Nascimento, Janílson & Fontinelle Silva, Gilnara & Pinto Bandeira, Kemuel. (2010). Usefulness of ultrasonography in children with suspected dengue hemorrhagic fever: A literature review. Radiologia Brasileira. 43. 401-407. 10.1590/ S0100-39842010000600013.

Santhosh VR et al,J Clin Imaging Sci. 2014 Mar 21;4:14. doi: 10.4103/2156-7514.129260. eCollection 2014.

Baskar C, Babu A.S.K.K.., Heber Anandan Clinical profile and outcome of dengue fever in pediatrics Paripex-Indian Journal Of Research, Volume : 5 | Issue : 10 |October 2016.

Surangrat Pongpana, Apichart Wisitwong, Chamaiporn Tawichasri, Jayanton Patumanond Prog-nostic Indicators for dengue infection severity, Int J Clin Pediatr• 2013;2(1):12-18. Doi: http://dx.doi. org/ 10. 4021/ ijcp73w


Refbacks

  • There are currently no refbacks.