The clinico-etiological profile of febrile seizure and its association with serum ferritin level

Shailendra Gautam, Pir Pratap Singh, Santosh Kumar Barman, Arun Kumar Arya

Abstract


Background: Febrile seizures are defined as an event in infancy or childhood, usually occurring between6 months and 5 years of age, associated with fever but without evidence of intracranial infection or other definable cause Thus, the present study was conducted to determine any association between serum ferritin level and first febrile seizure. Methods: A cross sectional study was conducted among the infants of age group 6 month to 5 year with complaints of fever with seizures attending Department of Pediatrics, GSVM Medical College, Kanpur for Feb. 2017 to Oct. 2018. After approval from Institutional Ethics Committee. Data was collected on pre deign case sheet consisting of general information history, clinical examination, temperature recording and relevant laboratory investigation such as hemoglobin, total leucocyte  count, differential leucocyte count and serum ferritin levels. Statistical analysis was done using SPSS (version 24.0; SPSS Inc., Chicago, IL, USA). Results: Study found that among 50 children, 40% children of febrile seizure belonged to age group 1 year to 2 years; febrile seizure was predominantly present in male population. Type of febrile seizure was predominantly simple febrile seizure (72%) and complex febrile seizure (28%). Results of GTCS it clearly indicate that there is statically significant association of GTCS with low serum ferritin level of less than 10 ng. Conclusions: In ferritin less than 10 ng, 29(90.6%) patients had GTCS and which was statistically significant. Association of cause of fever vs. serum ferritin was statistically significant. Larger studies are needed to confirm the present findings.

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References


Johnston MV. Febrile seizure. In: Behrman RE. Nelson textbook of Pediatrics, Philadelphia: Sunders; 2004: 1994-95.

Srinivasa S, Reddy SP. Iron deficiency anemia in children with simple febrile seizures - a cohort study. Curr Pediatr Res. 2014;18(2): 95-98.

Gencer H, Kafadar I, Kose G, Yildirmak Y. Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency. J Acad Res Med. 2016; 6 (2):94-7.

Kumari PL, Nair MK, Nair SM, et al. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012 Jan; 49(1):17-9. Epub 2011 May 30.

Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’ Apuzzo A, et al. Iron deficiency anemia and febrile convulsion: Case control study in children under 2 years. BMJ 1996; 313: 343.

Kobrinsky NL, Yager JY, Cheang MS, et al. Does iron deficiency raise the seizure threshold? J Child Neurol. 1995 Mar; 10(2):105-9. DOI: 10.1177/08830 7389501000207

Oski FA, Honig AS. The effects of therapy on the developmental scores of iron-deficient infants. J Pediatr. 1978 Jan; 92(1):21-5. DOI:10.1016/s0022-3476 (78) 80063-8

Johnston MV. Seizures in childhood: Febrileseizures. In: Behrman RE, Kliegman RM, JensonHB, editors. Nelson’s Textbook of Pediatrics. 17thed. Pennsylvania: Saunders; 2004. p. 1994-1995

Moruskar AD et al; Prospective study of iron deficiency status in febrile seizure patients at tertiary hospital Sangli. International J of Health care and biomedical research. 2016; 4 (3);40-48.

Potdar PS. Study of some epidemiological aspects of seizure disorders among children in rural of district. Int J Community Med Public Health .2018; 5: 2888-93.

Ghoshal S, Reynolds AS, Claassen J. Cyclic seizures- A clue to seizure termination? Clin Neurophysiol. 2017 Jun; 128 (6):1034-1036. DOI: 10. 1016 /j. clinph. 2017.02.014. Epub 2017 Mar 2.

Fallah R, Tirandazi B, Akhavan Karbasi S, et al. Iron deficiency and iron deficiency anemia in children with febrile seizure. Iran J Ped Hematol Oncol. 2013; 3(1):200-3. Epub 2013 Jan 22.

Naveed-ur-Rehman1, Billoo AG. Association between iron deficiency anemia and febrile seizures. J Coll Physicians Surg Pak. 2005 Jun;15(6):338-40. DOI: 06.2005/JCPSP.338340

Bidabadi E, Mashouf M. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure. 2009 Jun;18(5):347-51. DOI: 10.1016/j.seizure.2009.01.008. Epub 2009 Feb 15.

Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr. 2010 May;47(5):437-9. Epub 2009 Sep 3.

Waruiru C, Appleton R. Febrile seizures: an update. Arch Dis Child. 2004 Aug; 89(8):751-6. DOI:10.1136/ adc.2003.028449

Doud AS, Batiena A, Abu-Ekteish F. Eplipsia 2002 Jul; 43 (7): 740-3.

Susan A S, Keihani Doust Zarrin Taj, Mostafa A, Amin S, Zohreh K, Shahla A, Torkaman M, Yasaman G. Relationship between iron deficiency anaemia and febrile seizures. Iran J Child neurology 4(1); 2010:27-30

Nelson KB, Ellenberg JH. Prognosis in children with febrile seizures. Pediatrics. 1978 May;61(5):720-7.

Verity CM, Golding J. Risk of epilepsy after febrile convulsions: A national cohort study. BMJ. 1991 Nov 30; 303(6814): 1373–1376.

Zareifar S, Hosseinzadeh HR, Cohan N. Association between iron status and febrile seizures in children. Seizure. 2012 Oct; 21(8): 603-5. DOI: 10.1016/j. seizure. 2012. 06.010. Epub 2012 Jul 15.

Akbayram S, Cemek M, Büyükben A, et al. Major and minor bio-element status in children with febrile seizure. Bratisl Lek Listy. 2012;113(7):421-3.

Kumari PL, Nair MK, Nair SM, et al. Iron deficiency as a risk factor for simple febrile seizures--a case control study. Indian Pediatr. 2012 Jan; 49(1):17-9. Epub 2011 May 30.

Vaswani RK, Dharaskar PG, Kulkarni S, et al. Iron deficiency as a risk factor for first febrile seizure. Indian Pediatr. 2010 May; 47(5):437-9. Epub 2009 Sep 3.

Sherjil A, us Saeed Z, Shehzad S, et al. Iron deficiency anaemia--a risk factor for febrile seizures in children. J Ayub Med Coll Abbottabad. 2010 Jul-Sep; 22 (3):71-3.

Hartfield DS, Tan J, Yager JY, et al. The association between iron deficiency and febrile seizures in childhood. Clin Pediatr (Phila). 2009 May; 48 (4): 420-6. doi: 10.1177/ 0009922809331800. Epub 2009Feb 19.


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