Solitary Fibrous Tumor of Cerebellopontine angle – A case report and review of literature

Nouha Mahmood Alwani, Nazima Haider, Sohaila Fatima, Balkur Krishnamoorthi Adiga

Abstract


Solitary fibrous tumor is a rare mesenchymal neoplasm. It is ubiquitious in distribution with majority of the tumors arising within the thoracic cavity. Its categorization has changed many times but we present this case according to latest World Health Organization Central Nervous System tumor blue book classification where it has been grouped with hemangiopericytoma as one entity. We present a case of solitary fibrous tumor in cerebellopontine angle of brain in a 63 year old male. This case highlights the importance of immunohistochemistry markers in making a diagnosis and differentiating it from other mimickers.

Full Text:

PDF HTML

References


Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO Classification of Tumours of Soft Tissue and Bone. Pathology and Genetics of Tumours of Soft Tissue and Bone. 4th ed. Lyon: IARC Press, 2013:80-82.

Louis DN, Perry A, Reifenberger G et-al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131 (6): 803-20. doi:10.1007/s00401 -016-1545-1

Klemperer P, Coleman BR. Primary neoplasms of the pleura. A report of five cases. Am J Ind Med. 1992; 22(1):1-31.

Carneiro SS, Scheithauer BW, Nascimento AG, Hirose T, Davis DH. Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. Am J Clin Pathol. 1996 Aug;106(2):217-24.

Robinson DR, Wu YM, Kalyana-Sundaram S et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013 Feb;45(2):180-5. doi: 10.1038/ng.2509. Epub 2013 Jan 13.

Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring zimmermann's pericytes. Ann Surg. 1942 Jul;116(1):26-33.

Bailey P, Cushing H, Eisenchardt L. Angioblastic meningioma. Archives of Pathology and Laboratory Medicine. 1928 ;6:453–90.

Smith AB, Horkanyne-Szakaly I, Schroeder JW, Rushing EJ. From the radiologic pathology archives: mass lesions of the dura: beyond meningioma-radiologic- pathologic correlation. Radiographics. 2014 Mar-Apr; 34(2): 295-312. doi: 10. 1148/rg.34213 0075.

Bisceglia M, Galliani C, Giannatempo G, et al. Solitary fibrous tumor of the central nervous system: a 15-year literature survey of 220 cases (August 1996–July 2011). Adv Anat Pathol. 2011; Sep;18(5):356-92. doi: 10.1097/PAP.0b013e318229c004.

Wang XQ, Zhou Q, Li ST, Liao CL, Zhang H, Zhang BY. Solitary fibrous tumors of the central nervous system: clinical features and imaging findings in 22 patients. J Comput Assist Tomogr. 2013 Sep-Oct; 37 (5):658-65. doi: 10.1097/RCT.0b013e 3182a05687.

Khowaja A, Johnson-Rabbett B, Bantle J et-al. Hypoglycemia mediated by paraneoplastic production of Insulin like growth factor-2 from a malignant renal solitary fibrous tumor - clinical case and literature review. BMC Endocr Disord.14 (1): 49. doi:10.1186/ 1472-6823-14-49

Ginat DT, Bokhari A, Bhatt S, Dogra V. Imaging features of solitary fibrous tumors. AJR Am J Roentgenol. 2011 Mar; 196 (3):487-95. doi: 10.2214/ AJR. 10.4948.

Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH. Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer. 2004 Apr 1;100(7):1491-7. doi: 10. 1002/cncr.20109.

Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, Messina A, Pastorino U, Pierotti MA, Casali PG, Pilotti S. Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. Mol Cancer Ther. 2010 May; 9 (5):1286-97. doi: 10.1158/1535-7163.MCT-09-1205.


Refbacks

  • There are currently no refbacks.