Cover Image

Cytomorphological diagnosis of pilomatricoma in an unusual location

Nehal Ahmad, Mohd. Jaseem Hassan, Zeeba S Jairajpuri, Sabina Khan, Rubeena Naz, Sujata Jetley


Pilomatricomaisa benign skin adnexal tumor that is derived from hair matrix. Pilomatricomas usually present in children and adolescents but can occur at any age. Pilomatricomas are generally asymptomatic and found mainly in the head and neck area. Upper extremities not a common site for this lesion. It israrely identified on the chest, trunk, or lower extremities. They areeasily diagnosed on histology due to their typical histological features but diagnosis in cytology is generally difficult as the features may mimic other skin lesions and leads to misdiagnosis.

Here we describe a case of pilomatricoma of left arm in a 25 year old male, which was diagnosed on cytology. The cytological smears were cellular and consist of aggregates of anucleate squames, basaloid cells and shadow cells. Subsequent histopathologyof the excised lesion confirmed the diagnosis of Pilomatricoma. Through thisreport we highlight the cytomorphological features that helps us in arriving the correct diagnosis of Pilomatricomaon Fine needle aspiration cytology (FNAC) smears.

Full Text:



Reddy SS, Gadre SA, Adegboyega P, Gadre AK. Multiple pilomatrixomas: case report and literature review. Ear Nose Throat J. 2008 Apr; 8 (4) :230-3.

Yencha MW. Head and neck pilomatricoma in the pediatric age group: a retrospective study and literature review. Int J PediatrOtorhinolaryngol. 2001 Feb;57(2): 123-8.

Viero RM, Tani E, Skoog L.Fine needle aspiration (FNA) cytology of pilomatrixoma: report of 14 cases and review of the literature. Cytopathology. 1999 Aug; 10 (4):263-9.

O'Connor N, Patel M, Umar T, Macpherson DW, Ethunandan M. Head and neck pilomatricoma: an analysis of 201 cases. Br J Oral Maxillofac Surg. 2011 Jul; 49 (5):354-8. doi: 10.1016/j.bjoms.2010.06.002. Epub 2010 Jul 1.

Lan MY, Lan MC, Ho CY, Li WY, Lin CZ. Pilomatricoma of the head and neck: a retrospective review of 179 cases. Arch Otolaryngol Head Neck Surg. 2003 Dec;129(12):1327-30.

Farrier S, Morgan M. bcl-2 expression in pilomatricoma. Am J Dermatopathol. 1997 Jun; 19 (3): 254-7.

Goufman DB, Murrell GL, Watkins DV. Pathology forum. Quiz case 2. Pilomatricoma (calcifying epithe-lioma of Malherbe). Arch Otolaryngol Head Neck Surg. 2001;127:218-220.

Lemos MM, Kindblom LG, Meis-Kindblom JM, Ryd W, Willén H. Fine- needle aspiration features of pilomatrixoma. Cancer. 2001 Aug 25; 93 (4):252-6.

Wong MP, Yuen ST, Collins RJ. Fine-needle aspiration biopsy of pilomatrixoma: still a diagnostic trap for the unwary. Diagn Cytopathol.1994;10(4):365-9; discussion 369-70.

Lemos LB, Brauche RW. Pilomatrixoma: A diagnostic pitfall in fine needle aspiration biopsies: A review from small community hospital. Ann Diagn Pathol 2004; 8: 130-6.

Kumar N, Verma K. Fine needle aspiration (FNA) cytology of pilomatrixoma. Cytopathology. 1996 Apr; 7 (2) : 125-31.

Gomez AV, Azua J, San Pedro C, Romero J. Fine needle aspiration cytologic findings in four cases of pilomatrixoma (calcifying epithelioma of Malherbe). Acta Cytol 1990;34: 842-6.

Domanski HA, Domanski AM. Cytology of pilomatrixoma (calcifying epithelioma of Malherbe) in fine needle aspirates. Acta Cytol. 1997 May-Jun;41 (3): 771-7.

Sanchez SC, Bascunana AG, Quirante FAP, Robero MSM, Fernandez JC, Perez JS et al. Mimics of pilomatrixoma in fine needle aspirates. Diagn Cyto-pathol 1996;14: 75-83.

Moehlenbeck FW. Pilomatrixoma (calcifying epithelioma). A statistical study. Arch Dermatol. 1973 Oct; 108 (4):532-4.

Thomas RW, Perkins JA, Ruegemer JL, Munaretto JA. Surgical excision of pilomatrixoma of the head and neck: a retrospective review of 26 cases. Ear Nose Throat J. 1999 Aug; 78 (8):541, 544-6, 548.


  • There are currently no refbacks.