A study on cytology of soft tissue spindle cell tumors with histopathological correlation wherever possible

Dhanya K., Sateesh Chavan S

Abstract


Introduction: Spindle cell tumors constitute an important component of soft tissue tumors. Fine needle aspiration cytology provides a predictive diagnosis of type and nature of these neoplasms. Methods: This study was conducted for a period of four years. Results: A total of 124 cases were diagnosed as soft tissue spindle cell tumors cytologically. Of these, 86 (69.35%) cases were benign and 38 (30.64%) were malignant tumors. 52 cases were available for histopathological follow up of which 49 cases (94.23%) showed positive correlation. Though there are no specific tissue architectural patterns in cytological smears, they are helpful in providing predictive diagnosis of benign or malignant nature of the tumour and in many cases also of specific tumor type. However, histopathology is considered as “gold standard” in diagnosing spindle cell tumors. Ancillary techniques are helpful in providing definitive diagnosis thus increasing the diagnostic accuracy of FNAC. There were 2 false negative cases which were cytologically diagnosed as Schwannoma and Neurofibroma because of the presence of wavy spindle cells and blood but both cases were diagnosed as malignant peripheral nerve sheath tumor on histopathology. There was 1 false positive case cytologically diagnosed as malignant spindle cell tumor but histopathologically diagnosed as Pleomorphic lipoma. Conclusion: Cytological and histopathological correlation was available in 36 benign tumors and 16 malignant tumors. Among benign tumors, 94.44% (34 cases) showed positive correlation, 5.56% (2 cases) showed negative correlation. Whereas among malignant tumors, 93.75% (15 cases) showed positive correlation and 6.25% (1 case) showed negative correlation between cytologic and histopathologic diagnosis.

Full Text:

PDF

References


Weiss SW, Goldblum JR. General Considerations. Chapter-1 In: Enzinger and Weiss’s Soft Tissue Tumors. 4th Edition, St. Louis: Mosby. 2001:1-19.

Rosenberg AE. Bones, Joints and Soft Tissue Tumors. Chapter-26 In: Robbins and Cotran Pathologic Basis of Disease by Kumar, Abbas and Fausto, 7th Edition, Saunders: Elsevier, 2004;1273-1324

Beg S, Vasenwala SM, Haider N, Ahmad SS, Maheshwari V, Khan M. A comparison of cytological and histopathological findings and role of immunostains in the diagnosis of soft tissue tumors. J Cytol. 2012; 29 (2): 125-130. doi: 10.4103/0970-9371.97154.

Soni PB, Verma AK, Chandoke RK, Nigam JS. A prospective study of soft tissue tumors histocyto-pathology correlation. Pathol Res Int. 2014;2014: 678628. doi: 10. 1155/2014/ 678628. Epub 2014 Apr28.

Dey P, Mallik MK, Gupta SK, Vasishta RK. Role of fine needle aspiration cytology in the diagnosis of soft tissue tumours and tumour‐like lesions. Cytopathol. 2004;15(1):32-37.doi:10.1046/j.0956-5507.2003. 00102.x

Loya AC, Prayaga AK, Arora A, Sundaram C, Rao IS, Uppin SG, et al. Lymph node metastasis of soft tissue tumors: a cytomorphologic study.Acta Cytol. 2007; 51(2): 153-160. doi: 10.1159/ 000325708

Rekhi B, Gorad BD, Kakade AC, Chinoy R. Scope of FNAC in the diagnosis of soft tissue tumors--a study from a tertiary cancer referral center in India. Cyto J. 2007;4:20. doi:10.1186/1742-6413-4-20

Kilpatrick SE, Cappellari JO, Bos GD, Gold SH, Ward WG. Is fine-needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of sarcoma? Experience with 140 patients. Am J Clin Pathol. 2001;115(1):59-68. doi:10.1309/ YN14-K8U4- 5FLJ-DGJE

Costa MJ, Campman SC, Davis RL, Howell LP. Fine-needle aspiration cytology of sarcoma: retros-pective review of diagnostic utility and specificity. DiagnCytopathol. 1996;15(1):23-32.doi:10.1002/(SICI) 1097-0339(199607)15:1<23::AID-DC6>3.0.CO; 2-R.

Wakely PE Jr, Kneisl JS. Soft tissue aspiration cytopathology. Cancer. 2000;90(5):292-298. doi: https: //doi.org/10.1002/1097-0142(20001025)90:5<292:: AID-CNCR5> 3.0.CO;2-8


Refbacks

  • There are currently no refbacks.